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Effect of INT-777 on PC2 expression. PC2 mRNA expression in αTC1-6 cells (A), control mouse islets (B), and human islets (C) cultured for 7 days under low (5 mm) or high (25 mm) glucose (G) conditions in the presence or absence of INT-777 (25 μm) for 48 h. D, PC2 mRNA expression in db/db mouse islets treated with or without INT-777 (25 μm) for 48 h. Data are expressed as the mean ± S.E. of three experiments.
