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. 2016 Jan 12;291(13):6626–6640. doi: 10.1074/jbc.M115.699504

FIGURE 7.

FIGURE 7.

INT-777 improves insulin sensitivity and glucose tolerance in db/db mice. Wild type and db/db mice were treated with vehicle (Veh) (DMSO) or INT-777 (30 mg/kg/day) intraperitoneally for 7 weeks (n = 10 per group). Body weights (A), fasting blood glucose concentration (B), fasting plasma insulin (C), and HOMA-IR values (D) were calculated based on the following formula: (fasting insulin (milliunits/liter) × fasting glucose (mmol/liter))/22.5. E, blood glucose concentration (mg/dl) after intraperitoneal injection of 1 g/kg glucose. F, blood glucose concentration (mg/dl) after administration of 0.75 units/kg insulin. Inset depicts the area under curve (AUC) with or without treatment of INT-777 in db/db mice. Data are expressed as the mean ± S.E. of three experiments. #, p < 0.05, or ##, p < 0.001, compared with wild type mice; *, p < 0.05, or **, p < 0.001, compared with db/db mice. HOMA-IR, Homeostatic Model Assessment for Insulin Resistance. AU, arbitrary units.