FIGURE 9.

DSS-induced colitis in Pla2g4a^−/−, Pla2g6^−/−, and Ptges^−/− mice. WT (n = 9), Pla2g4a^−/− (n = 4), Pla2g6^−/− (n = 5), and Ptges^−/− (n = 10) mice were administered 1% DSS orally. Body weight (A) and clinical score (B) were monitored at the indicated times, and colon histology (bar, 100 μm) (C), spleen weight (D), hematocrit (E), and ES-MS profiles of colorectal lipids (F) were evaluated at day 7. There were no differences in the measured parameters among the genotypes under normal conditions (data not shown). Mean ± S.E., *, p < 0.05, and **, p < 0.01.