FIGURE 6.

KLK5 silencing reduces tumor inflammatory infiltrate. A–C, inflammatory cells were enumerated from H&E-stained sections for each high power field containing or immediately adjacent to tumor nests. Results were presented as counts per high power field. Magnification A and B, ×200. *, p = 0.001. D–F, tumor sections were evaluated for mast cell infiltration by staining for mast cell tryptase using murine anti-tryptase (1:100) and the Vector M.O.M. (mouse-on-mouse) kit according to the manufacturer's specifications. Tryptase-positive mast cells were quantified as described under “Materials and Methods.” Magnification C and D, ×200. *, p = 0.004.