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HFD feeding attenuates the effects of deletion of the hepatic Ahr gene on insulin sensitivity. AhRflox/flox mice and AhR LKO mice were fed a chow diet or HFD for 12 weeks before being analyzed (n = 6). A, glucose tolerance test. B, insulin tolerance test. The area under the curve (AUC) was calculated for respective group. #, p < 0.05 relative to AhRflox/flox mice fed a chow diet. *, p < 0.05 relative to AhRflox/flox mice on the same diet.
