FIGURE 6.
Generation of AhR LKO mice expressing transgene of the Socs3. A, schematic representations of the transgene construct. The transgene is under the control of the mouse albumin promoter. B, representative Western blot of SOCS3, phosphorylated STAT3, total STAT3, and β-actin in the liver extract. Each lane was run using samples from two different male mice. AhRflox/flox mice, AhR LKO mice, AhR LKO/S3 Tg mice, and S3 Tg mice were fed a HFD. C, body weight of mice fed a chow diet or HFD for 10 weeks (n = 5–7). D, tissue weight of mice fed a chow diet or HFD for 10 weeks (n = 5–7).