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. 2016 Feb 10;291(13):7004–7016. doi: 10.1074/jbc.M115.693655

FIGURE 7.

FIGURE 7.

Rescue of Socs3 expression in AhR LKO mice attenuates HFD-induced steatosis. AhRflox/flox mice, AhR LKO mice, AhR LKO/S3 Tg mice, and S3 Tg mice were fed a chow or HFD for 10 weeks (n = 5–7). A, representative H&E staining of the liver section (magnification, ×100. Scale bar, 50 μm). B, triglyceride content in the liver. C, qRT-PCR analysis of the expression of lipogenic genes. D, de novo lipogenesis activity in the mouse liver of mice fed a HFD. #, p < 0.05 relative to AhRflox/flox mice fed a chow diet. *, p < 0.05 relative to AhRflox/flox mice fed a HFD (in B and D) or AhRflox/flox mice fed a same diet (C). +, p < 0.05 relative to AhR LKO mice fed a HFD.