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. 2016 Feb 3;291(13):7070–7086. doi: 10.1074/jbc.M116.714873

FIGURE 3.

FIGURE 3.

cPLA2α activation promotes COX-2 expression. a, Western blot of cPLA2α, COX-1, COX-2, and β-actin in cPLA2α+/+ and cPLA2α−/− RPM incubated with C. albicans (CA) for 3 and 6 h is shown. b, Western blot of COX-2 and β-actin in cPLA2α+/+ and cPLA2α−/− RPM treated for 30 min with and without Cay10441 (1 μm), 8-Br-cAMP (8-Br; 2 mm), iloprost (Ilo; 1 μm), and butaprost (But; 10 μm) and then incubated with C. albicans for 6 h. c, Western blot of COX-2 and β-actin in cPLA2α+/+ RPM treated for 30 min with the indicated concentrations of the IP (CAY10441), EP2 (PF-04418948), and EP4 (L-161,982) receptor antagonists alone (left) or in combination (right) and then incubated with C. albicans for 6 h. Results are representative of three independent experiments.