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Steady-state rate inhibition experiments. A, Michaelis-Menten and Lineweaver-Burk plots of NADH inhibition of SIRT1-mediated deacetylation using substrate 3b (LGKac) at varying substrate or NAD+ concentrations. B, Michaelis-Menten and Lineweaver-Burk plots of NADH inhibition of SIRT5-mediated desuccinylation of substrate 3p (LGKsuc) at varying substrate or NAD+ concentrations.
