Table 1.

Histopathologic subtypes of duodenal adenocarcinoma

Phenotype	Histological characteristics	Histologically similar	Immunophenotype markers	Prognosis
Intestinal	Tubular/cribiforming glands lined by columnar neoplastic cells	Colonic adenocarcinoma	MUC2, CD10, CDX2	+
Gastric	Tubular/papillary proliferation with foveolar or pyloric-type differentiation	Gastric adenocarcinoma	MUC5AC, MUC6	-
Pancreaticobiliary	Simple glands of cuboidal/columnar cells with rounded pleomorphic nuclei; prominent desmoplastic stroma	Pancreatic and Extrahepatic bile duct adenocarcinoma	MUC1	-
Indeterminate	Poor differentiation	None	MUC1	-

Adapted from Ushiku et al[22].