TABLE 1 .
SNP frequencies during passage of HPIV3 strain CI-13
| Position (nt) | Major variant | Minor variant | ORF | Coding difference | Kinetics | SNP frequency (%) on: |
||
|---|---|---|---|---|---|---|---|---|
| Day 1 | Day 3 | Day 7 | ||||||
| 396 | G | T | NP | V96F | D | 18 | 5 | 2 |
| 398 | C | T | NP | V96F | D | 18 | 0 | 1 |
| 400 | A | G | NP | K97R | D | 8 | 0 | 0 |
| 403 | A | T | NP | Y98F | D | 7 | 0 | 0 |
| 407 | C | T | NP | None | D | 7 | 0 | 0 |
| 409 | T | A | NP | I100K | D | 7 | 0 | 0 |
| 414 | A | T | NP | M102L | D | 7 | 5 | 0 |
| 430 | T | A | NP | L107Q | I | 0 | 4 | 0 |
| 438 | C | T | NP | Q110* | D | 13 | 4 | 0 |
| 439 | A | G | NP | Q110* | D | 13 | 0 | 0 |
| 459 | G | T | NP | V117F | D | 29 | 27 | 9 |
| 462 | A | G | NP | K118E | D | 28 | 26 | 8 |
| 1967 | T | C | P | C62R | I | 0 | 7 | 0 |
| 1967 | T | C | C | None | I | 0 | 7 | 0 |
| 5404 | T | A | F | F111L | I | 1 | 4 | 0 |
| 7620 | C | G | HN | P272R | D | 3 | 0 | 0 |
| 10585 | A | T | L | D647V | D | 10 | 0 | 0 |
| 13811 | G | A | L | None | D | 8 | 0 | 1 |
| 13934 | T | G | L | None | D | 7 | 5 | 1 |
| 13999 | T | G | L | L1785R | D | 7 | 2 | 0 |
| 14247 | G | T | L | V1868F | D | 8 | 0 | 0 |
| 14912 | C | T | L | None | D | 10 | 0 | 2 |
| 15042 | T | A | L | S2133T | D | 9 | 0 | 1 |
| 15227 | C | A | L | None | I | 0 | 7 | 1 |
| 15273 | C | A | L | P2210T | D | 7 | 0 | 0 |
| 15277 | G | A | L | R2211K | I | 0 | 11 | 0 |
| 15288 | G | A | L | E2215K | I | 0 | 4 | 0 |
| 15292 | C | A | L | P2216H | I | 0 | 9 | 0 |
| 15294 | G | A | L | E2217K | I | 0 | 4 | 2 |
| 15314 | C | A | L | N2223K | I | 0 | 11 | 2 |
| 15317 | C | A | L | Y2224* | I | 0 | 12 | 0 |
| 15324 | C | A | L | H2227N | D | 10 | 0 | 2 |
| 15338 | T | A | L | D2231E | D | 9 | 0 | 0 |
| 15342 | G | A | L | D2233K | D | 10 | 0 | 0 |
| 15344 | T | A | L | D2233K | D | 10 | 0 | 0 |