Table 2.
Histone variants overexpressed in AI-resistant disease
| Gene | Q value |
|---|---|
| HIST1H1B | 0.0072 |
| HIST1H1D | 0.0011 |
| HIST1H2AE | 3.00E−04 |
| HIST1H2AI | 0.0054 |
| HIST1H2AJ | 0.0039 |
| HIST1H2AL | 0.0096 |
| HIST1H2AM | 0.0186 |
| HIST1H2BB | 0.048 |
| HIST1H2BF | 0.0051 |
| HIST1H2BG | 0.0299 |
| HIST1H2BH | 4.00E−04 |
| HIST1H2BK | 0.0229 |
| HIST1H2BL | 0.048 |
| HIST1H2BM | 0.0299 |
| HIST1H3B | 0.0347 |
| HIST1H3D | 0.0039 |
| HIST1H3E | 0.0096 |
| HIST1H3F | 2.00E−04 |
| HIST1H3G | 0.0146 |
| HIST1H3H | 0.0148 |
| HIST1H4K | 0.0238 |
| HIST2H3C | 0.0096 |
Raw values from nCounter platform were normalized to the geometric mean of positive controls followed by normalization to the geometric mean of the housekeeping genes to adjust for sample content. Statistical methods were applied to the log-transformed data and comparisons between cases and controls were made using the two-sample t test controlling the false-discovery rate at 5 %