Fig. 5.
The therapeutic effect of 3,6′-DT treatment is abolished in mice lacking TNF receptors. Wild-type mice (WT) and TNF receptor-deficient mice (TNFR KO) were treated with either vehicle or 56 mg/kg 3,6′-DT 1 hr prior to MCAO/R (five or six mice per group). A: Examples of TTC-stained serial brain sections from mice at 72 hr after ischemic stroke. Infarct volumes (B) and neurological deficit scores (C) are shown. **P < 0.01 compared with the value for vehicle-treated mice. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]