FIG 6.

Virulence of LAC xerC mutants in hematogenous infection. Mice were infected by tail vein injection with the indicated strains. Tissues were harvested either upon compassionate euthanasia or after 6 days. The results shown are the colony counts obtained from each tissue in individual mice, with the horizontal line within each group indicating the mean within that experimental group (A to C). Permutation-based ANOVA models were used to analyze these data. The numbers above each group are P values for that group compared to the result for the isogenic parent strain. NS, not significant. (D) Kaplan-Meier survival curves for mice hematogenously infected with LAC and its isogenic xerC or sarA mutant. Log rank tests were used to compare the results for the mutant and parent strains. *, statistically significant difference by comparison to the result for the parent strain.