FIG 6.

Development of a type I-skewed immune environment in skeletal muscles from chronically T. cruzi-infected mice. Mice were euthanized after developing atrophy and/or partial or total paralysis of the posterior limbs (10 to 12 months p.i.). Expression of mRNAs for the indicated factors was determined by real-time RT-PCR. Filled circles, infected mice (I); open circles, age-matched uninfected controls (U). Data are from one experiment and are presented as individual values and medians. Statistical analysis was performed by the Mann-Whitney test.