FIG 9.

Cardiac fibrosis and dysfunction in chronically T. cruzi-infected mice. Mice were analyzed 7 months after infection with T. cruzi. (A and B) Gomori's trichrome stain for collagen. Images in panel A are representative of a total of 12 animals whose fibrosis varied in severity, as scored in panel B. Magnification, ×400. (C) Ejection fraction measured by ultrasound of infected or age-matched uninfected control mice. The dotted line represents the lower limit of the 99% confidence interval of ejection fractions for uninfected mice (P < 0.05; Fisher's exact test); odds ratios were not statistically significantly different. The solid horizontal lines indicate the medians for the groups analyzed. Data were pooled from 2 independent experiments.