TABLE 5.

Signaling pathways during infection with different pneumococcal strains^a

Pathway	P value
	BALB/c mice				CBA/Ca mice
	D39 (ST2)	BHN418 (ST6B)	LgtSt215 (ST19f)	BS71 (ST3) (lethal)	D39 (ST2) (lethal)	BHN248 (ST6B) (lethal)	LgtSt215 (ST19f)	BS71 (ST3) (lethal)
Cytokine-cytokine receptor interaction	3.92E−07	9.10E−07	3.70E−07		2.38E−08	5.30E−04	8.20E−04	7.20E−03
Toll-like receptor signaling pathway	3.32E−04	7.70E−06	3.20E−05		1.33E−06	1.00E−03	1.60E−07	3.30E−02
Chemokine signaling pathway	9.02E−03	3.20E−04	7.80E−04		5.10E−05		2.30E−05
MAPK signaling pathway	1.93E−05	4.30E−02	1.30E−03		1.08E−04		1.20E−02	1.10E−02
B-cell receptor signaling pathway	3.10E−03	1.30E−02	2.00E−03		4.43E−05		5.40E−04
Hematopoietic cell lineage	1.20E−03	3.40E−03	4.40E−04			3.00E−03	3.20E−03	3.00E−04
Apoptosis	1.57E−03	4.10E−03	3.00E−03		1.09E−04	8.40E−02	4.00E−03	2.40E−02
Pathways in cancer	2.92E−05	2.60E−02	4.00E−02		6.33E−07
Adipocytokine signaling pathway		6.20E−03	7.80E−04		1.56E−04		7.40E−04
Jak-STAT signaling pathway	1.88E−04	1.70E−02	1.30E−02		3.02E−03		5.20E−03
NOD-like receptor signaling pathway	8.63E−03	2.30E−02			5.88E−03		3.60E−02
Cytosolic DNA-sensing pathway					1.05E−02		5.40E−03
Natural killer cell-mediated cytotoxicity					9.83E−04
Prion diseases								2.60E−02
Fc gamma R-mediated phagocytosis							8.20E−03
Axon guidance	3.92E−03
Complement and coagulation cascades								1.60E−02
Alzheimer's disease								4.00E−02
p53 signaling pathway	4.33E−03
T-cell receptor signaling pathway					6.06E−03

^aGene expression was evaluated by comparison of infected mice and PBS-treated mice. The significance (P value) of each pathway is presented.