TABLE 7.
Comparative GO analysis (DAVID) of DEGsa
| GO term | Shared genes |
Unique genes |
||
|---|---|---|---|---|
| Mouse P value | Pathogen P value | Mouse P value | Pathogen P value | |
| Immune response | 2.30E−07 | 1.40E−02 | 1.10E−07 | |
| Immune effector process | 2.70E−05 | 1.40E−03 | ||
| Defense response | 1.10E−03 | 2.30E−04 | ||
| Positive regulation of immune response | 3.80E−03 | 8.40E−03 | ||
| Response to cytokine stimulus | 9.90E−03 | 2.00E−03 | ||
| Leukocyte-mediated immunity | 8.10E−04 | |||
| Positive regulation of response to stimulus | 1.80E−03 | |||
| Immunoglobulin-mediated immune response | 3.20E−03 | |||
| B-cell-mediated immunity | 3.50E−03 | |||
| Lymphocyte-mediated immunity | 5.50E−03 | |||
| Adaptive immune response | 7.20E−03 | |||
| Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 7.20E−03 | |||
| Negative regulation of molecular function | 2.00E−07 | |||
| Negative regulation of catalytic activity | 3.10E−04 | |||
| Chemotaxis | 4.20E−04 | 3.10E−07 | ||
| Taxis | 4.20E−04 | 3.10E−07 | ||
| Cell chemotaxis | 3.40E−03 | |||
| Leukocyte chemotaxis | 3.40E−03 | |||
| Locomotory behavior | 7.30E−03 | 2.20E−04 | ||
| Leukocyte migration | 8.50E−03 | 5.90E−03 | ||
| Behavior | 9.60E−03 | 5.40E−04 | ||
| Negative regulation of kinase activity | 5.90E−04 | |||
| Negative regulation of protein kinase activity | 5.90E−04 | |||
| Negative regulation of transferase activity | 6.60E−04 | |||
| Negative regulation of myeloid cell differentiation | 2.10E−03 | |||
| Negative regulation of transcription factor activity | 2.30E−03 | |||
| Negative regulation of cell differentiation | 2.80E−03 | 3.80E−03 | ||
| Negative regulation of DNA binding | 3.20E−03 | |||
| Negative regulation of binding | 4.20E−03 | |||
| Antigen processing and presentation | 2.90E−03 | |||
| Response to molecule of bacterial origin | 1.10E−07 | |||
| Inflammatory response | 1.40E−06 | |||
| Response to lipopolysaccharide | 2.90E−06 | |||
| Vasculature development | 5.50E−06 | |||
| Response to wounding | 7.10E−06 | |||
| Regulation of cell proliferation | 1.40E−05 | |||
| Angiogenesis | 1.60E−05 | |||
| Response to organic substance | 1.60E−05 | |||
| Blood vessel development | 1.80E−05 | |||
| Positive regulation of cell differentiation | 4.30E−05 | |||
| Positive regulation of immune system process | 4.90E−05 | |||
| Positive regulation of developmental process | 7.30E−05 | |||
| Response to bacterium | 7.40E−05 | |||
| Regulation of tumor necrosis factor production | 7.90E−05 | |||
a
Shared genes indicate the list of genes associated with both survival and either mouse strain or pneumococcal strain. Unique genes indicate the list of genes associated with only one of the studied factors: host (mouse) or pneumococcal strain. The significance (P value) of each GO term is presented.