FIG 5.

Effects of uricase and DNase I on infection with EPEC E22 in rabbit ileal loops in vivo. (A) Lack of effect of uricase on recovery of EPEC E22 bacteria from intestinal loops. (B) Effects of micrococcal nuclease and DNase I on recovery of E22 from rabbit ileal loops. †, micrococcal nuclease just missed statistical significance on E22 bacterial counts. (C) Effect of DNase I on myeloperoxidase activity in the fluid recovered from the ileal loop. (D) Effects of uricase and DNase I on myeloperoxidase in intestinal-loop fluids. (E) Effect of DNase I on histological damage in the ileum, as measured by the villus-to-crypt ratio, an index of villus blunting. (F) Effect of DNase I on the noncoliform aerobic bacteria recovered on MacConkey agar in intestinal loops treated with DNase I (right petri dish; the arrows indicate non-lactose-fermenting colonies) compared to intestinal loops infected with E22 alone (left petri dish; almost all the colonies are coliforms). The error bars indicate SD.