FIG 7.

Architecture of domains in the NRPSs TxtA and TxtB. NRPSs contain four conserved domains: adenylation (AMP), methyltransferase (MET), peptidyl carrier protein (PP), and condensation (COND). In the cases of TxtA (top) and TxtB (bottom), the MET domain is embedded within the C-terminal region of the AMP domain. TxtA of all 4 Streptomyces plant pathogens and TxtB of S. ipomoeae contain the MET12 (methyltransferase type 12) domain, while TxtB in S. scabies, S. acidiscabies, and S. turgidiscabies contains the methyltransferase type 11 domain. Alignments and conserved residues are shown in blue.