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. 2016 Mar 25;11:13. doi: 10.1186/s13062-016-0117-6

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© Kim et al. 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 10 — Stress-induced transitions to high-cortisol oscillating state. a Projected 2D system dynamics when a stressor of amplitude I _ext=0.2 is applied for 9 min starting at T=120 min. c is increased just above the unstable branch (c≈20) to allow the unstressed system to cross the separatrix and transition to the normal high-c stable state. b The plot of o(T) shows the transition to the high-cortisol, high-oscillation amplitude state shortly after the 9 min stress. c A stressor turned off after 780 min (13 hrs) leaves the system in the basin of attraction of the diseased state. d Cortisol levels are pushed up but after about 1400 min relax back to levels of the original diseased state