Table 1.

Dimensionless parameter values of our full model

Parameter	Value	Source and Ref.	Description
n	5	Assumed	Hill coefficient in upregulation function g c(c)
${\overline{c}}_{\infty }$	0.2	Estimated from [22]	Baseline stored CRH level
b	0.6	Estimated from [22]	Relates cortisol to stored CRH level
k	Undetermined	·	Relates stored CRH to CRH release rate
μ c	Undetermined	·	Basal CRH release rate
q 0	Undetermined	·	Maximum CRH release rate
$q_1^{-1}$	Undetermined	·	Circulating CRH for half-maximum self-upregulation
q 2	1.8	Estimated from [21]	Ratio of CRH and cortisol decay rates
$p_2^{-1}$	0.067	$p_2^{-1}$ [13]	(o r)-complex level for half-maximum feedback
p 3	7.2	p 3 [13]	Ratio of ACTH and cortisol decay rates
p 4	0.05	p 4 [13]	(o r)-complex level for half-maximum upregulation
p 5	0.11	p 5 [13]	Basal GR production rate by pituitary
p 6	2.9	p 6 [13]	Ratio of GR and cortisol decay rates
t c	69.3	Assumed	CRH biosynthesis timescale
t d	1.44	“ τ” [13]	Delay in ACTH-activated cortisol release