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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Am J Geriatr Psychiatry. 2016 Jan 29;24(3):248–258. doi: 10.1016/j.jagp.2015.12.002

Table 3.

Variability in Objective Sleep Measures and Odds of MCI or Dementia

Outcome = MCI or Dementia vs. Normal
Minimally Adjusteda Multivariate Adjustedb

Predictor (SD over all nights) OR (95% CI) Wald χ2 [1, N=1242], p-value OR (95% CI) Wald χ2 [1, N=1220], p-value
Total Sleep Time, minutes
    Q1 (<28.58) 1.00 (reference) - - 1.00 (reference) - -
    Q2 (28.58 to <42.16) 0.81 (0.58-1.14) 1.49, p = 0.22 0.82 (0.58-1.17) 1.21, p = 0.27
    Q3 (42.16 to <61.04) 0.96 (0.68-1.34) 0.07, p = 0.79 0.98 (0.69-1.38) 0.02, p = 0.89
    Q4 (≥61.04) 1.36 (0.97-1.91) 3.26, p = 0.07 1.40 (0.98-1.98) 3.47, p = 0.06
    p-trend 4.02, p = 0.045 4.05, p = 0.04
Sleep Efficiency, %
    Q1 (<2.99) 1.00 (reference) - - 1.00 (reference) - -
    Q2 (2.99 to <4.93) 1.83 (1.30-2.57) 12.00, p = 0.0005 1.89 (1.33-2.69) 12.50, p = 0.0004
    Q3 (4.93 to <7.92) 1.43 (1.01-2.02) 4.11, p = 0.04 1.48 (1.04-2.12) 4.60, p = 0.03
    Q4 (≥7.92) 1.87 (1.32-2.64) 12.65, p = 0.0004 1.92 (1.34-2.75) 12.74, p = 0.0004
    p-trend 8.40, p = 0.004 8.66, p = 0.003
Wake After Sleep Onset, minutes
    Q1 (<11.64) 1.00 (reference) - - 1.00 (reference) - -
    Q2 (11.64 to <20.33) 1.31 (0.94-1.83) 2.52, p = 0.11 1.29 (0.91-1.82) 2.10, p = 0.15
    Q3 (20.33 to <37.44) 1.21 (0.86-1.69) 1.17, p = 0.28 1.22 (0.86-1.73) 1.26, p = 0.26
    Q4 (≥37.44) 1.24 (0.88-1.75) 1.54, p = 0.21 1.25 (0.87-1.78) 1.48, p = 0.22
    p-trend 1.04, p = 0.31 1.11, p = 0.29
Sleep Latency, minutes
    Q1 (<10.10) 1.00 (reference) - - 1.00 (reference) - -
    Q2 (10.10 to <18.15) 1.00 (0.71-1.40) 0.00, p = 1.00 0.98 (0.69-1.38) 0.02, p = 0.90
    Q3 (18.15 to <33.89) 0.94 (0.67-1.32) 0.11, p = 0.74 0.92 (0.65-1.31) 0.20, p = 0.66
    Q4 (≥33.89) 1.36 (0.98-1.91) 3.30, p = 0.07 1.37 (0.97-1.94) 3.20, p = 0.07
    p-trend 2.66, p = 0.10 2.60, p = 0.11
a

Adjusted for age, race, clinic and education

b

Adjusted for age, race, clinic, education, body mass index, number of depressive symptoms, comorbidities, number of IADL impairments, smoking status, alcohol use, exercise, living alone, self-reported health status, antidepressant use, benzodiazepine use, and prescription sleep medication use.

A separate model was run for each predictor.

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