. Author manuscript; available in PMC: 2016 Mar 25.

Published in final edited form as: J Autism Dev Disord. 2008 Dec 19;39(5):720–729. doi: 10.1007/s10803-008-0675-2

Table 3.

Schedule for switching subjects from risperidone to aripiprazole

	Risperidone	Aripiprazole^c
		>25 kg	≤25 kg
Day 57 (week 8)^a	75% of dose^b	2.5 mg	2.5
Day 61		5.0 mg	(no increase)
Day 64 (week 9)	50% of dose	7.5 mg	5.0
Day 71 (week 10)	25% of dose	10 mg	7.5
Day 78 (week 11)	Stop	12.5 mg	10
Day 85 (week 12)		15 mg	12.5
Day 92 (week 13)^d		20 mg^d	15

Switch could occur as early as week 4

Evening dose decreased first; subsequent decreases were made one day after the study visit

Aripiprazole started in the morning; could switch to bedtime to manage sedation. The upward adjustment could be delayed to manage adverse effects. The dose could be decreased at any time to manage adverse effects

This dose increase was optional in case of incomplete response and the increase may be a similar increment if all prior increases were not made