TABLE 5.
Relation between omega-3 index and CES-D scores ≥16 at baseline and at 2-y follow-up stratified by 8-OHdG concentration among older Puerto Rican adults1
| 8-OHdG concentration |
||||
| Outcome | Unstratified | Tertile 1 | Tertile 2 | Tertile 3 |
| CES-Dbaseline ≥162 | ||||
| 8-OHdG concentration,3 ng/μg creatinine | 132 ± 3 (6.8–390) | 62.7 ± 1.79 (6.8–96.4) | 124 ± 1.37 (96.6–156) | 209 ± 3.72 (156–390) |
| n | 524 | 174 | 175 | 175 |
| Prevalence, n (%) | 263 (50) | 87 (50) | 85 (49) | 91 (52) |
| Model4 | ||||
| 1 | 0.94 (0.82, 1.08) | 1.02 (0.77, 1.36) | 1.07 (0.84, 1.35) | 0.68 (0.52, 0.90) |
| 2 | 0.98 (0.85, 1.13) | 1.07 (0.79, 1.43) | 1.06 (0.83, 1.35) | 0.73 (0.55, 0.97) |
| 3 | 1.00 (0.86, 1.15) | 1.07 (0.79, 1.43) | 1.08 (0.83, 1.39) | 0.72 (0.53, 0.96) |
| CES-D2y ≥165 | ||||
| 8-OHdG concentration,3 ng/μg creatinine | 133 ± 3.19 (7.7–390) | 63.8 ± 1.96 (7.7–96.6) | 124 ± 1.42 (96.6–155) | 209 ± 3.91 (156–390) |
| n | 453 | 151 | 151 | 151 |
| Prevalence, n (%) | 175 (39) | 62 (41) | 50 (33) | 63 (42) |
| Model4,6 | ||||
| 1 | 0.89 (0.76, 1.04) | 0.81 (0.60, 1.10) | 1.06 (0.83, 1.36) | 0.75 (0.56, 1.01) |
| 2 | 0.89 (0.76, 1.04) | 0.86 (0.62, 1.19) | 1.09 (0.84, 1.40) | 0.82 (0.60, 1.12) |
| 3 | 0.94 (0.80, 1.12) | 0.86 (0.62, 1.20) | 1.01 (0.84, 1.43) | 0.83 (0.60, 1.15) |
Values are ORs (95% CIs) unless otherwise noted. Multivariable logistic regression was used to determine the relation between the omega-3 index and CES-D scores ≥16 at baseline and at 2-y follow-up. CES-D, Center for Epidemiological Studies–Depression Scale; 8-OHdG, 8-hydroxy-2-deoxyguanosine.
Excluded participants reporting antidepressant use at baseline (n = 263).
Values are unadjusted mean ± SE (minimum–maximum) 8-OHdG concentrations.
Model 1 adjusted for age and sex; model 2 adjusted as in model 1 plus for current smoker, physical activity score, high school education, diabetes, and cardiovascular disease; model 3 adjusted as in model 2 plus for Healthy Eating Index 2005 score (excluding oil component).
Excluded those reporting antidepressant use at baseline or follow-up (n = 334).
CES-D2y models were additionally adjusted for time between visits.