TABLE 2.
OR (95% CIs) of myocardial infarction cases per plus one risk allele according to intake of sugar-sweetened beverages (n = 3311)1
| Sugar-sweetened beverages, servings/d |
||||
| <1 | 1–2 | >2 | P-interaction | |
| rs4977574 | ||||
| Model 1 | 1.02 (0.87, 1.20) | 1.24 (1.04, 1.48) | 1.28 (1.07, 1.52) | 0.06 |
| Model 2 | 0.97 (0.81, 1.16) | 1.22 (1.01, 1.48) | 1.45 (1.20, 1.75) | 0.005 |
| Model 3 | 0.97 (0.81, 1.16) | 1.21 (1.00, 1.47) | 1.44 (1.19, 1.74) | 0.005 |
| rs2383206 | ||||
| Model 1 | 1.04 (0.88, 1.23) | 1.20 (1.01, 1.43) | 1.19 (1.00, 1.42) | 0.27 |
| Model 2 | 1.00 (0.83, 1.19) | 1.21 (1.00, 1.46) | 1.28 (1.06, 1.55) | 0.10 |
| Model 3 | 1.00 (0.83, 1.20) | 1.20 (0.99, 1.46) | 1.28 (1.06, 1.55) | 0.09 |
| rs1333049 | ||||
| Model 1 | 1.07 (0.90, 1.26) | 1.12 (0.94, 1.34) | 1.25 (1.05, 1.48) | 0.19 |
| Model 2 | 1.05 (0.87, 1.26) | 1.10 (0.91, 1.34) | 1.33 (1.11, 1.60) | 0.11 |
| Model 3 | 1.05 (0.87, 1.26) | 1.09 (0.90, 1.33) | 1.34 (1.11, 1.61) | 0.10 |
1
Unconditional logistic regression was used to calculate ORs of myocardial infarction. In model 1, adjustments included age and sex; in model 2, adjustments further included genetic admixture (proportion of Amerindian and West African ancestral ethnicities), alcohol intake, cigarette smoking, prevalent disease status (diabetes, hypertension, and dyslipidemia), household income, area of residence, family history of myocardial infarction, physical activity, regular aspirin intake, and caloric intake; in model 3, adjustments further included BMI.