TABLE 2.
Association between adipose tissue n–3 FAs and insulin resistance in the AHS-2 calibration study (n = 716)1
| FA | Model 1 | Model 2 | Model 3 |
| ALA | −0.40 (−0.50, −0.29)* | −0.28 (−0.40, −0.17)* | −0.13 (−0.23, −0.02)*** |
| EPA plus DHA | −0.12 (−0.44, 0.20) | −0.17 (−0.48, 0.14) | 0.01 (−0.28, 0.25) |
| Total n–3 FAs | −0.34 (−0.44, −0.25)* | −0.24 (−0.34, −0.14)* | −0.10 (−0.19, −0.01)*** |
1
All values are β coefficients; 95% CIs in parentheses. Associations were determined with the use of a multivariable regression analysis. Model 1 was adjusted for age, sex, race, and energy intake. Model 2 was adjusted as for model 1 and for physical activity, adipose tissue SFA, and high-sensitivity C-reactive protein. Model 3 was adjusted as for model 2 and for waist circumference. *,***Significant association between insulin resistance and adipose tissue FAs: *P < 0.0001, ***P < 0.05. AHS-2, Adventist Health Study-2; ALA, α-linolenic acid; FA, fatty acid.