TABLE 1.
Estimated reductions in all-cause mortality, total CVD, and CVD mortality corresponding to reductions in LDL cholesterol associated with nut consumption of 1 serving/d1
| CTT Collaboration (9) | Del Gobbo et al. (5) | |
| Design | Meta-analysis of individual data from 27 randomized trials | Meta-analysis of 61 controlled trials |
| Interventions | Regular statin therapy | Nuts per 1 serving/d |
| Subgroups | Participants without CVD2 | Adults without CVD but with higher LDL cholesterol3 |
| Mean/median duration | 4.8 y | 4 wk |
| Baseline LDL cholesterol, mmol/L | 3.704 | ≥3.362 |
| Reductions in LDL cholesterol, mmol/L | 1.00 | 0.113 |
| RR (95% CI) | ||
| All-cause mortality | 0.91 (0.85, 0.97)5 | 0.989 (0.982, 0.997)6 |
| Total CVD | 0.75 (0.70, 0.80)5 | 0.968 (0.960, 0.975)6 |
| CVD deaths | 0.85 (0.77, 0.95)5 | 0.982 (0.971, 0.994)6 |
1
CTT, Cholesterol Treatment Trialists’; CVD, cardiovascular disease.
2
To be comparable with the meta-analysis by Del Gobbo et al. (5), results from subgroups of participants without CVD were selected.
3
To be comparable with the CTT Collaboration, results from subgroups of participants with higher baseline LDL cholesterol (>130 mg/dL) were selected.
4
Mean value for all participants (SD: 0.7 mmol/L).
5
Reported risk estimates for participants without history of CVD.
6
Estimated RRs corresponding to reductions in LDL cholesterol associated with nut consumption of 1 serving/d.