Table 1.
Patient Characteristics among subjects with Sudden Cardiac Arrest (Cases) and with no episodes of Sudden Cardiac Arrest (Controls).
| All | Cases (n=272) |
Controls (n=351) |
P value |
|---|---|---|---|
| Age | 68.7 ± 14.6 | 67.6 ± 11.4 | 0.312 |
| Male | 173 (63.6%) |
217 (63.3%) | 0.931 |
| Hypertension | 219 (80.5%) |
268 (76.4%) | 0.212 |
| White Non-Hispanic | 216 (79.4%) |
314 (89.5%) | <0.00 1 |
| African American | 33 (12.1%) | 12 (3.4%) | <0.00 1 |
| Diabetes | 134 (49.3%) |
119 (33.9%) | <0.00 1 |
| BMI (kg/m2) | 30.2 ± 9.8 | 30.0 ± 6.8 | 0.823 |
| Cholesterol (mg/dL) | 171.0 ± 48.8 |
172.0 ± 50.0 | 0.748 |
| Current Smoker | 62 (22.8%) | 57 (16.2%) | 0.039 |
| Chronic renal insufficiency | 100 (36.8%) |
57 (16.2%) | <0.00 1 |
| Dialysis | 30 (11.0%) | 2 (0.6%) | <0.00 1 |
| Class I Antiarrhythmic medication | 12 (2.4%) | 12 (4.5%) | 0.153 |
| Class III Antiarrhythmic medication | 24 (9.1%) | 9 (2.7%) | 0.001 |
| Severe LV Dysfunction† | 68 (25.3%) | 43 (12.3%) | <0.00 1 |
| Echocardiographic LVH‡ | 100 (40.8%) |
66 (19.8%) | <0.00 1 |
| QRS Duration (ms) | 105 ± 25 | 100 ± 21 | 0.011 |
| QTc Duration (ms) | 469 ± 48 | 433 ± 36 | <0.00 1 |
| QTc Prolongation§ | 156 (57.4%) |
78 (22.7%) | <0.00 1 |
| Heart Rate (bpm) | 76.9 ± 17.6 | 69.4 ± 15.7 | <0.00 1 |
| JTc Duration (ms) | 364 ± 45.1 | 334 ± 35.2 | <0.00 1 |
| JTc Prolongation (75th %)¶ | 152 (56.3%) |
87 (24.9%) | <0.00 1 |
| Intrinsicoid Deflection ≥ 0.05 s | 77 (28.3%) | 60 (17.1%) | 0.001 |
| Both JTc Prolongation and Intrinsicoid Deflection ≥ 0.05 s |
41 (15.2%) | 14 (4.0%) | <0.00 1 |
Data are presented as n (%) or mean ± SD. LV-Left Ventricular; LVH-Left Ventricular Hypertrophy; BMI-Body Mass Index
†
Severe LV Dysfunction data available for 618 subjects
‡
Echo LVH data available for 579 subjects
§
Women ≥ 470 ms, Men ≥ 450 ms. QTc prolongation data available for 615 subjects
¶
JTc interval ≥355ms. JTc prolongation data available for 620 subjects