. 2016 Mar 25;11(3):e0152476. doi: 10.1371/journal.pone.0152476

Table 1. Associations with celiac disease or tissue transglutaminase autoantibody (tTGA) positivity (p<10⁻⁴), mapped to previously known regions.

SNP^a	CHR	BP	MAF	HR CD	P-value^b CD	HR tTGA	P-value^b tTGA	# SNPS (P<10⁻⁴)	Nearby Gene
rs1936670	1	190598185	0.02	2.23	5.10x10^-5	1.36	0.038	1	RGS21
rs4851575	2	102391635	0.24	1.45	5.69x10^-5	1.16	0.014	49	IL18R1, IL18RAP
rs114569351	2	68520426	0.02	2.64	4.19x10^-5	1.73	0.002	1	PLEK,FBXO48
rs12493471	3	45926682	0.36	1.40	6.36x10^-5	1.09	0.098	1	CCR9,LZTFL1,CXCR6
rs1054091	6	159389500	0.17	1.59	5.81x10^-6	1.22	0.004	2	RSPH3,TAGAP
rs12990970	2	204408934	0.38	0.82	0.027	0.76	1.26x10^-6	21	NPM1P33,CTLA4
rs11709472	3	189560280	0.45	0.82	0.019	0.80	2.75x10^-5	8	LPP

CHR: Chromosome; BP: Base Pair Position (NCBI 36.3); MAF: Minor Allele Frequency; HRCD: Hazard Ratio in celiac disease analysis; HRtTGA: Hazard Ratio in tTGA analysis. P-values < 10⁻⁴ are highlighted in bold

^aThe data for the SNP with smallest p-value is presented from each region.

^bHRs and p-value adjusted for family history of celiac disease, HLA-DR-DQ genotype, gender, HLA-DPB1, population stratification (ancestral heterogeneity) and country of residence (as strata).

Table 1. Associations with celiac disease or tissue transglutaminase autoantibody (tTGA) positivity (p<10−4), mapped to previously known regions.

Table 1. Associations with celiac disease or tissue transglutaminase autoantibody (tTGA) positivity (p<10⁻⁴), mapped to previously known regions.