Table 2. Novel associations with celiac disease or tissue transglutaminase autoantibody (tTGA) positivity (p<10−4).
| SNPa | CHR | BP | MAF | HR CD | P-valueb CD | HR tTGA | P-valueb tTGA | # SNPS (P<10−4) | Nearby Gene |
|---|---|---|---|---|---|---|---|---|---|
| rs72704176 | 1 | 153692482 | 0.02 | 2.26 | 7.42x10-5 | 1.31 | 0.085 | 1 | ASH1L |
| rs3771689 | 2 | 159930048 | 0.14 | 0.56 | 9.27x10-5 | 0.85 | 0.037 | 2 | BAZ2B |
| rs13014907 | 2 | 185781851 | 0.01 | 2.46 | 5.99x10-5 | 1.45 | 0.050 | 1 | ZNF804A |
| rs11739460 | 5 | 149685099 | 0.40 | 1.41 | 2.88x10-5 | 1.05 | 0.319 | 2 | TCOF1 |
| rs77532435 | 7 | 50641412 | 0.03 | 2.05 | 4.82x10-5 | 1.38 | 0.015 | 1 | GRB10 |
| rs6967298 | 7 | 69652445 | 0.19 | 0.61 | 9.42x10-5 | 0.90 | 0.137 | 1 | AUTS2 |
| rs61751041 | 7 | 107381421 | 0.02 | 2.23 | 9.76x10-5 | 1.61 | 0.002 | 1 | LAMB1 |
| rs72717025 | 1 | 159736883 | 0.02 | 1.41 | 0.207 | 1.84 | 9.61x10-5 | 1 | FCGR2A |
| rs114157400 | 4 | 103154484 | 0.04 | 1.71 | 0.003 | 1.62 | 8.43x10-5 | 2 | BANK1 |
| rs2409747 | 8 | 11115872 | 0.11 | 1.58 | 9.28x10-5 | 1.37 | 5.37x10-5 | 1 | XKR6 |
| rs117561283 | 12 | 66732860 | 0.03 | 1.96 | 0.002 | 1.81 | 2.14x10-5 | 1 | IFNG |
| rs8013918 | 14 | 74779319 | 0.45 | 0.85 | 0.066 | 0.80 | 4.91x10-5 | 1 | FOS |
CHR: Chromosome; BP: Base Pair Position (NCBI 36.3); MAF: Minor Allele Frequency; HRCD: Hazard Ratio in celiac disease analysis; HRtTGA: Hazard Ratio in tTGA analysis. P-values < 10−4 are highlighted in bold
aThe data for the SNP with smallest p-value is presented from each region.
bHRs and p-value adjusted for family history of celiac disease, HLA-DR-DQ genotype, gender, HLA-DPB1, population stratification (ancestral heterogeneity) and country of residence (as strata).