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. 2016 Mar 25;11(3):e0152104. doi: 10.1371/journal.pone.0152104

Fig 4. pERK, B-RAF and Dabrafenib in silico dynamics.

Fig 4

pERK concentrations decrease during Dabrafenib treatment in A375 melanoma cell line. The behavior of pERK is directly correlated to the Dabrafenib concentration. Different dosages of Dabrafenib are shown (1nM = 1e-9 mmol/ml): 1.25e-10 mmol/ml (A), 2.5e-10 mmol/ml (B), 5e-10 mmol/ml (C), 1e-9 mmol/ml (D) and 2e-9 mmol/ml (E). In all the panels the right y-axis dotted lines represent bRafMutated concentrations while solid lines represent Dabrafenib concentrations.