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. Author manuscript; available in PMC: 2016 Mar 25.
Published in final edited form as: Bioorg Med Chem. 2014 Sep 15;22(21):6053–6061. doi: 10.1016/j.bmc.2014.09.002

Figure 5.

Figure 5

a) Progress curve analysis of PfENR inhibition at various concentrations of compound 1 in the presence of varying concentrations of crotonyl-CoA (3.22 × 10−4 – 40 μM) and 50 μM NAD+ preincubation. b) Double-reciprocal plot of varying celastrol concentrations (● 0 μM, ■ 9.7 × 10−2 μM, ▲7.8 × 10−2 μM, and ▼ 12.5 μM) in order to access inhibition behavior. The average values were plotted and all experiments were collected in triplicate.