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. Author manuscript; available in PMC: 2016 Mar 25.
Published in final edited form as: Horm Behav. 2015 Jul 16;76:63–80. doi: 10.1016/j.yhbeh.2015.06.021

Figure 1. Model of AβPP Differential Processing During hESC Differentiation.

Figure 1

The processing of AβPP towards the amyloidogenic pathway promotes hESC proliferation (pink box) whereas non-amyloidogenic processing induces hESC differentiation into NPCs (blue box). Inhibition of β-secretase cleavage of AβPP (red cross) significantly suppresses hESC proliferation and promotes nestin expression and NPC formation. Addition of secreted AβPPα suppresses hESC proliferation and promotes the formation of NPCs.