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. 2016 Mar 25;11(3):e0152280. doi: 10.1371/journal.pone.0152280

Fig 4. Protein-protein interaction network and signaling pathway analysis.

Fig 4

(A) A PPI network, as shown in the interactive view, generated by a STRING database to reveal functional interactions between up-regulated proteins. Each node represents a protein, and each edge represents an interaction (P-values = 6.06E-12); (B) Up-regulated proteins’ MCL cluster algorithms derived using STRING. MCL = 2; (C) Up-regulated proteins’ K-Means cluster algorithms. K-Means = 4; approximate same consequences by two clusters; (D) A PPI network reveals functional interactions between down-regulated proteins (P-value = 1.47E-6); (E) Down-regulated proteins’MCL cluster algorithms. MCL = 2; (F) Down-regulated proteins’ K-Means cluster algorithms. K-Means = 4.