Table 4.

Pharmacokinetic parameters of olodaterol after administration of a single inhaled dose of 30 μg to subjects with severe renal impairment and healthy subjects

Parameter	Unit	Severe renal impairment			Healthy subjects
		n	gMean	gCV%	n	gMean	gCV%
Cmax	pg·mL−1	7	11.1	96.3	13	8.15	48.0
tmaxa	hours	7	0.383	0.233–0.717	13	0.233	0.133–1.08
AUC0–4	pg·h·mL−1	7	23.4	65.4	13	17.3	36.8
AUC0–tz	pg·h·mL−1	7	37.5	159	13	27.6	104
tz,plasmaa	hours	7	12.1	2.05–24.1	13	6.08	2.07–48.1
CLR,0–8	mL·min−1	7	35.9	48.4	13	179	64.2
fe0–tz	%	8	0.411	161	14	2.31	107
tz,urinea	hours	8	48.0	12.0–72.0	14	72.0	24.0–72.0

Note:

^aMedian and range.

Abbreviations: gMean, geometric mean; gCV, geometric coefficient of variation; C_max, maximum observed plasma concentration; t_max, time to C_max; AUC, area under the curve; t_z, time to last quantifiable plasma or urine concentration; CL_R, renal clearance; fe, fraction of dose excreted in the urine.