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. 2016 Mar 18;9:1647–1656. doi: 10.2147/OTT.S96518

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© 2016 Wu et al. This work is published and licensed by Dove Medical Press Limited

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Knockdown of MTA2 suppresses growth and metastasis of CNE2 cells in vivo.

Notes: (A) Tumor size and tumor weight of CNE2/shNC and CNE2/shMTA2 groups in nude mice 3 weeks after injection of control or CNE2/shMTA2 cells subcutaneously in the right subaxillary. (B) Observation of pulmonary metastasis foci (black arrow) of nude mice 6 weeks after injection of control or CNE2/shMTA2 cells through tail vein (H&E ×100, ^*P<0.01). (C) Levels of MTA2, pAkt, cyclin D1, and MMP7 proteins in subcutaneous tumors of CNE2/shNC and CNE2/shMTA2 groups.

Abbreviations: MTA2, metastasis-associated gene 2; H&E, hematoxylin and eosin; MMP7, matrix metalloproteinase 7.