Table 3. Uni- and multivariate analyses of rpS6 and p-rpS6 expression and clinical/pathologic features for the prediction of cancer specific survival in patients with RCCs.

	Univariate Analysis		Multivariate Analysis
	Hazard Ratio (95 % CI)	p	Hazard Ratio (95 % CI)	p
rpS6 & p-rpS6	1.7 (1.3-2.3)	<0.001	1.9 (1.4-2.6)	<0.001
Karnofsky*	2.6 (1.9-3.4)	<0.001	1.6 (1.2-2.2)	0.002
Tumor extent◦	5.7 (4.2-7.8)	<0.001	2.9 (2-4.2)	<0.001
Regional lymph node metastasis•	7.1 (4.9-10.1)	<0.001	1.6 (1.1-2.4)	0.03
Distant metastasis±	10.6 (7.7-14.4)	<0.001	5.1 (3.5-7.3)	<0.001
Grade of malignancy⊗	5.4 (3.9-7.3)	<0.001	1.8 (1.3-2.5)	0.001
Type of surgeryt	4.5 (2.1-9.7)	<0.001	1.9 (0.9-4.3)	0.10
Sex =	1.6 (1.2-2.2)	0.003	1.3 (0.9-1.8)	0.15
Histopathologic subtype<	1.6 (1.2-2.2)	0.003	1.2 (0.7-1.9)	0.5
p-rpS6 Expression∗	1.9 (1.4-2.6)	<0.001	1.4 (1-1.9)	0.03
Karnofsky*	2.3 (1.8-3)	<0.001	1.7 (1.3-2.2)	<0.001
Tumor extent◦	5.6 (4.2-7.5)	<0.001	2.8 (2-3.8)	<0.001
Regional lymph node metastasis•	6.8 (4.9-9.5)	<0.001	1.7 (1.2-2.5)	0.006
Distant metastasis±	10.8 (8.1-14.4)	<0.001	5 (3.6-7)	<0.001
Grade of malignancy⊗	5.3 (4-7)	<0.001	1.9 (1.4-2.6)	<0.001
Type of surgeryt	3.4 (1.9-6)	<0.001	1.2 (0.7-2.3)	0.51
Sex =	1.6 (1.2-2.2)	0.001	1.4 (1-1.9)	0.04
Histopathologic subtype<	1.6 (1.2-2.2)	0.001	1.1 (0.7-1.8)	0.56
rpS6 Expression∗	1.8 (1.4-2.4)	<0.001	1.8 (1.4-2.4)	<0.001
Karnofsky*	2.5 (1.9-3.2)	<0.001	1.7 (1.3-2.3)	<0.001
Tumor extent◦	5.9 (4.3-7.9)	<0.001	2.8 (2-3.9)	<0.001
Regional lymph node metastasis•	5.9 (4.2-8.3)	<0.001	1.4 (0.9-2)	0.13
Distant metastasis±	10.3 (7.7-13.8)	<0.001	4.9 (3.5-6.8)	<0.001
Grade of malignancy⊗	5.8 (4.3-7.7)	<0.001	1.9 (1.4-2.6)	<0.001
Type of surgeryt	5 (2.4-10.1)	<0.001	1.9 (0.9-3.9)	0.1
Sex =	1.6 (1.2-2.2)	0.001	1.5 (1.1-2)	0.015
Histopathologic subtype<	1.6 (1.2-2.2)	0.001	1.1 (0.7-1.8)	0.6

^∗Immunistochemical intensity low vs. high

^*<80% vs >= 80%

^◦pT3/pT4 vs pT1/pT2

^•pN1/pN2 vs pN0/N0

^±M0 vs M1

^⊗G1/G2 vs G3/G4

⁼Male vs female

^tRadical vs partial nephrectomy

^<Clear-cell (conventional) vs other types