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. 2015 Nov 22;7(1):524–537. doi: 10.18632/oncotarget.6358

Figure 1. PBLD is aberrantly downregulated in human HCCs.

Figure 1

A. The relative mRNA expression of PBLD in HCC tissues was decreased when compared with the matched adjacent non-tumorigenic tissues by qRT-PCR (n = 108, P < 0.001) (top). Additionally, PBLD expression was markedly higher in well-differentiated HCC tissues as compared with moderate to poorly-differentiated HCC tissues (bottom). B. Representative immunohistochemical staining for PBLD in adjacent non-tumorous liver tissues (a, ×200; b, ×400), and in well (c, ×200), moderately (f, ×400), and poorly (d, ×200) differentiated HCC tissues. The staining for PBLD was dramatically decreased in HCC tissues as compared with that shown for non-tumorous liver tissues, which showed a sharp contrast between the tumorous area (“T”) and the adjacent non-tumorous area (“NT”) (e, ×200). C. PBLD protein expression was detected in the 48 paired of HCC and matched adjacent non-tumorous tissues as determined by western blotting.