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. 2015 Nov 22;7(1):524–537. doi: 10.18632/oncotarget.6358

Table 2. Univariate and multivariate analyses of factors associated with RFS and OS in patients with HCC.

RFS OS
HR (95%CI) P value HR (95%CI) P value
Univariate analysis
Age, yrs (<50 vs. ≥50) 0.994 (0.973-1.015) 0.553 0.659 (0.315-1.534) 0.368
Gender (male vs. female) 1.160 (0.046-2.910) 0.753 1.037 (0.307-3.507) 0.953
HBsAg (negative vs. positive) 1.996 (0.622-6.400) 0.245 1.627 (0.383-6.913) 0.509
HBeAg (negative vs. positive) 0.929 (0.420-2.054) 0.856 2.457 (0.831-7.262) 0.104
AFP,ng/ml (≤400 vs. >400) 1.847 (1.081-3.156) 0.025 3.016 (1.326-6.859) 0.008
Liver cirrhosis (absent vs. present) 0.886 (0.493-1.594) 0.686 0.792 (0.341-1.838) 0.587
Vascular invasion (absent vs. resent) 2.183 (1.167-4.084) 0.015 4.228 (1.798-9.942) 0.001
Intrahepatic metastasis (absent vs. present) 3.674 (2.056-6.566) 0.000 3.079 (1.270-7.764) 0.013
Tumor size, cm (≤5 vs. >5) 2.884 (1.358-6.125) 0.006 1.720 (0.644-4.589) 0.279
Tumor number (single vs. multiple) 3.464 (1.932-6.211) 0.000 2.622 (1.038-6.622) 0.041
Differentiation (poor/moderate vs. well) 1.986 (1.084-3.641) 0.026 3.729 (1.391-10.000) 0.009
AJCC stage(I-II vs. III-IV) 3.131 (1.805-5.430) 0.000 5.081 (2.273-11.360) 0.000
PBLD (low vs. high) 0.447 (0.260-0.769) 0.004 0.384 (0.165-0.894) 0.027
Multivariate analysis
Tumor size, cm (≤5 vs. >5) 2.839 (1.270-6.345) 0.011
AJCC stage (I-II vs. III-IV) 2.400 (1.137-5.066) 0.022 9.349 (1.754-49.842) 0.009
PBLD (low vs. high) 0.502 (0.282-0.891) 0.019 0.364 (0.138-0.957) 0.040