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. 2015 Nov 23;7(1):565–579. doi: 10.18632/oncotarget.6376

Figure 6. Dasatinib does not induce oncogene-induced senescence.

Figure 6

Non-small cell lung cancer cell lines with kinase-inactivating BRAF mutations (Cal12T, H1666) or wild-type BRAF (H661, A549) were incubated with 150nM dasatinib for the indicated times (A, C) or for 72 hours (B) Activation of the MEK/ERK pathway was measured using Western blot analysis with the indicated antibodies A. or quantitative polymerase chain reaction for downstream transcriptional targets B. Error bars represent standard deviation. *P < 0.05 compared with control. C. The production of reactive oxygen species was estimated using a fluorogenic probe that exhibits fluorescence upon oxidation by reactive oxygen species.