Table 4. Top metabolic pathways implicated in progression of melanoma.
| Pathway | Nevus vs Skin | Pr. Mel vs Skin | Met. Mel vs Skin | Met. Mel vs Pr. Mel | Primary vs Nevus |
|---|---|---|---|---|---|
| allopregnanolone biosynthesis | UP | DOWN | DOWN | DOWN | DOWN |
| citrulline-nitric oxide cycle | UP | DOWN | DOWN | DOWN | DOWN |
| dTMP ide novoi biosynthesis mitochondrial | DOWN | UP | UP | UP | UP |
| L-carnitine biosynthesis | UP | DOWN | DOWN | DOWN | DOWN |
| 5-aminoimidazole ribonucleotide biosynthesis | DOWN | UP | UP | UP | UP |
| eumelanin biosynthesis | UP | UP | UP | DOWN | DOWN |
| putrescine biosynthesis II | DOWN | DOWN | UP | UP | UP |
| pyrimidine deoxyribonucleosides salvage | DOWN | UP | UP | UP | UP |
| spermine and spermidine degradation I | UP | DOWN | DOWN | DOWN | DOWN |
| superpathway of tryptophan utilization | UP | DOWN | DOWN | UP | DOWN |
| tryptophan degradation X mammalian via tryptamine | UP | DOWN | DOWN | DOWN | DOWN |
| 1D-imyoi-inositol hexakisphosphate biosynthesis V from Ins134P3 | UP | UP | DOWN | DOWN | UP |
| D-mannose degradation | UP | UP | UP | UP | DOWN |
| fructose 26-bisphosphate synthesis, dephosphorylation | UP | UP | UP | DOWN | DOWN |
| histamine biosynthesis | UP | DOWN | DOWN | DOWN | DOWN |
| inosine-5-phosphate biosynthesis | UP | UP | UP | UP | DOWN |
| melatonin degradation II | UP | DOWN | DOWN | DOWN | DOWN |
| pyrimidine deoxyribonucleosides degradation | UP | UP | UP | DOWN | UP |
| resolvin D biosynthesis | UP | UP | UP | DOWN | UP |
| retinoate biosynthesis I | DOWN | DOWN | DOWN | UP | UP |
| superpathway of steroid hormone biosynthesis | UP | DOWN | DOWN | DOWN | DOWN |
| tRNA charging | UP | UP | UP | UP | UP |
| UDP-N-acetyl-D-galactosamine biosynthesis II | UP | UP | UP | UP | DOWN |
| valine degradation | DOWN | DOWN | DOWN | UP | DOWN |
| zymosterol biosynthesis | UP | DOWN | DOWN | DOWN | DOWN |
UP or DOWN indicates positive and negative difference between the state of interest (nevus, primary and metastatic melanoma) and skin in median PAS value, respectively.