Skip to main content
. 2015 Nov 26;7(1):671–683. doi: 10.18632/oncotarget.6400

Figure 1. TAL6 protein is over-expressed in lung cancer cells and clinical lung tumor tissues.

Figure 1

A. TAL6 protein levels were measured on the cell surface by flow cytometry using mouse anti-TAL6 antibody (green line) or isotype control antibody (shaded), and then probed with goat anti-mouse FITC-conjugated antibody in 9 lung cancer cell lines. B. TAL6 expression in primary cultured lung cancer cells from pleural effusion was detected by flow cytometry as in panel A. PE53 and PE8 were established from two individual lung cancer patients. C. TAL6 expression was stained in xenograft tumors from SCID mice by subcutaneously injecting primary cultured lung cancer cells. D. The IHC staining from stage III lung cancer patients and cancer adjacent normal pneumonic lung tissue. An enlarged image is shown below the original IHC stains. E. IHC analysis of TAL6 in lung cancer tissue array scored by staining intensity from 0 to 3+ (0, negative; 1, weak; 2, moderate; 3, strong) by histologists. Positive is taken as a score of greater than 0; negative is indicated by score = 0. F. Analysis of IHC scores in tumor and adjacent normal tissue. G. ROC curve analysis for prediction of TAL6 expression in lung tumor tissues from IHC results of lung cancer tissue array. The AUC is 0.75 and the sensitivity and specificity is 70.6% and 70.6%.