Table 5. Canonical pathway analysis in the 231 DEGs.

Pathway	Genes in Gene Set	Genes in Overlap	Gene Symbol	P-value	FDR
Steroid biosynthesis	17	4	SQLE, DHCR7, NSDHL, DHCR24	0.00000118	0.000475
DNA replication	36	4	MCM2, MCM5, DNA2, RPA1	0.0000272	0.0031
Lysosome	121	6	GAA, CTSA, TCIRG1, CTSF, LAPTM4A, NAGA	0.000028	0.0031
Endocytosis	183	7	RAB11FIP5, RAB5B, RAB11FIP2, RAB11A, NEDD4, LDLR, HSPA1B	0.0000321	0.0031
Cell cycle	128	6	CDKN2C, MCM2, GADD45A, MCM5, CDC7, YWHAG	0.0000385	0.0031
Glycosaminoglycan biosynthesis - keratan sulfate	15	3	B3GNT1, ST3GAL3, FUT8	0.0000478	0.00321
Lysine degradation	44	4	PLOD1, ACAT2, HADH, EHMT2	0.0000608	0.0035
CDK Regulation of DNA Replication	18	3	MCM2, MCM5, CDT1	0.0000849	0.00428
MAPK signaling pathway	267	7	CHUK, GADD45A, IL1A, RPS6KA1, HSPA1B, DUSP1, JUND	0.000334	0.0149
ECM-receptor interaction	84	4	SDC1, ITGB5, DAG1, COL1A1	0.000743	0.0299