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. 2015 Nov 24;7(1):745–758. doi: 10.18632/oncotarget.6378

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Copyright: © 2016 Mayr et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A. Dose-dependent effect of single treatment with PTC-209 or cisplatin (n = 6). Blue line indicates viable cells after PTC-209 treatment, black line indicates viable cells after cisplatin treatment, respectively. B. Effect of combined PTC-209 and cisplatin treatment on GBC cells. Each cell represents a combination of specific concentrations of PTC-209 and cisplatin, respectively (n = 6). The first number (bold) indicates the CI and the second number shows the percentage of viable cells of the respective combination after 72 h compared to untreated cells. The calculation of the CI is based on the cell viability values of the single (A) and combined treatments. A CI smaller than 0.9 indicates a synergistic effect, whereas a CI between 0.9 and 1.1 represents an additive effect [22]. Synergistic combinations are highlighted with grey background. Abbreviations: CI: combination index; h: hours; n.d.: not determined.