Table 1. Associations of stromal POSTN expression with demographic and clinical variables of 755 CRC patients in Shanghai cohort.
| Characteristics | Stromal POSTN expression in tumor specimens | |||
|---|---|---|---|---|
| Low (n = 444) | Medium (n = 222) | High (n = 89) | P value | |
| Age (years), mean (SD) | 60.33 (12.77) | 58.96 (13.23) | 57.61 (11.97) | 0.133 |
| Sex, n (%) | ||||
| Women | 193 (43.5) | 90 (40.5) | 37 (41.6) | 0.761 |
| Men | 251 (56.5) | 132 (59.5) | 52 (58.4) | |
| Disease location, n (%) | ||||
| Colon | 210 (47.3) | 102 (45.9) | 42 (47.2) | 0.945 |
| Rectum | 234 (52.7) | 120 (54.1) | 47 (52.8) | |
| Differentiation grade, n (%) | <0.001 | |||
| Well | 16 (3.6) | 8 (3.6) | 1 (1.1) | |
| Moderately | 269 (60.6) | 119 (53.6) | 36 (40.4) | |
| Poorly | 125 (28.2) | 79 (35.6) | 49 (55.1) | |
| Missing | 34 (7.7) | 16(7.2) | 3(3.4) | |
| Number of lymph nodes, n (%) | 0.607 | |||
| <12 | 198 (44.6) | 96 (43.2) | 44 (49.4) | |
| ≥12 | 246 (55.4) | 126 (56.8) | 45 (50.6) | |
| TNM stage, n (%) | <0.001 | |||
| I | 40 (9.0) | 10 (4.5) | 2 (2.2) | |
| II | 193 (43.5) | 94 (42.3) | 24 (27.0) | |
| III | 190 (42.8) | 87 (39.2) | 42 (47.2) | |
| IV | 21 (4.7) | 31 (14.0) | 21 (23.6) | |
| Adjuvant chemotherapy, n (%) | <0.001 | |||
| Yes | 362 (81.5) | 199 (89.6) | 86 (96.6) | |
| No | 82 (18.5) | 23 (10.4) | 3 (3.4) | |
| Serum CEA | ||||
| <5 ng/mL | 283 (63.7) | 133 (59.9) | 50 (56.2) | 0.374 |
| ≥5 ng/mL | 161 (36.3) | 89 (40.1) | 38 (42.7) | |
| Missing | 0 (0) | 0 (0) | 1 (1.1) | |
| Serum CA19-9 | ||||
| <37 U/ml | 379 (85.4) | 180 (81.1) | 68 (76.4) | 0.123 |
| ≥37 U/ml | 65 (14.6) | 41 (18.5) | 20 (22.5) | |
| Missing | 0 (0) | 1 (0.5) | 1 (1.1) | |
a
Student-Newman-Keuls q test
b
Pearson Chi-Square test
c
Kruskal-Wallis test.