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. 2015 Oct 15;7(1):961–975. doi: 10.18632/oncotarget.5830

Figure 3. Linc-POU3F3 knockdown inhibited the proliferation of CRC cells via cell cycle arrest.

Figure 3

A. CellTiter 96 AQueous One Solution Cell Proliferation assay showing the proliferation in LOVO, SW480, and RKO cells after siRNA transfection. B. Histological analysis of the rate of colony formation in controls and linc-POU3F3 knockdown groups. C. The EdU incorporation assay to examine the effects of linc-POU3F3 inhibition on the DNA synthesis during cell growth. The images were taken at × 200. D. Flow cytometric analysis of cell cycle arrest 48 hours after treatment with siRNAs and negative controls in LOVO, SW480, and RKO cells. E–F. The expression of several important cell cycle-related proteins in linc-POU3F3 knockdown CRC cells. (Mean ± SD, n = 3; *P < 0.05 vs. NC).