Table 4. strata analysis results : independents factors associated with Time to diagnosis, identified by multivariate analyses, for each tumor site.
| Breast cancer | Prostate cancer | Sarcoma | Lung cancer | Colorectal cancer | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| univariate | multivariate | univariate | multivariate | univariate | multivariate | univariate | multivariate | univariate | multivariate | |||||||||||
| HR [95%CI] | p (LR) | HR [95%CI] | p (LR) | HR [95%CI] | p (LR) | HR [95%CI] | p (LR) | HR[CI] | p (LR) | AHR [CI] | p (LR) | HR [95%CI] | p (LR) | AHR [95%CI] | p (LR) | HR [95%CI] | p (LR) | AHR [95%CI] | p (LR) | |
| AGE | 0.68 [0.28-1.62] | 0.71 [0.27-1.9] | 1 (reference) | 0.845 | 1 (reference) | 0.726 | 1 (reference) | 0.879 | ||||||||||||
| [19-55] | 1 (reference) | 0.419 | 1 (reference) | 0.04 | 1 (reference) | 0.034 | 0.66 [0.23-1.9] | 0.86 [0.52-1.43] | 0.98 [0.54-1.77] | |||||||||||
| [56-65] | 1.17 [0.94-1.47] | 0.54 [0.36-0.81] | 0.52 [0.33-0.8] | 1.11 [0.35-3.57] | 1.05 [0.64-1.72] | 1.17 [0.65-2.12] | ||||||||||||||
| [66-74] | 1.19 [50.92-1.53] | 0.67 [0.43-1.04] | 0.55 [0.34-0.9] | 0.84 [0.37-1.89] | 1.1 [0.62-1.94] | 1.12 [0.62-2] | ||||||||||||||
| [75-92] | 1.12 [0.87-1.44] | |||||||||||||||||||
| GENDER | ||||||||||||||||||||
| Female | 1 (reference) | 0.649 | NA | NA | 1 (reference) | 0.172 | 1 (reference) | 0.623 | 1 (reference) | 0.848 | 1 (reference) | 0.89 | ||||||||
| Male | 1.32 [0.42-4.11] | 0.6 [0.29-1.23] | 0.78 [0.29-2.08] | 1.04 [0.73-1.47] | 0.97 [0.67-1.42] | |||||||||||||||
| ECOG PS | ||||||||||||||||||||
| 0 | 1 (reference) | 0.287 | 1 (reference) | 0.005 | 1 (reference) | 0.09 | 1 (reference) | 0.009 | 1 (reference) | 0.102 | 1 (reference) | 0.359 | 1 (reference) | 0.433 | ||||||
| 1 | 0.81 [0.64-1.02] | 0.84 [0.59-1.2] | 0.41 [0.18-0.92] | 0.23 [0.09-0.61] | 1.26 [0.79-2.01] | 1.47 [0.8-3.38] | 1.4 [0.92-2.14] | |||||||||||||
| 2 | 1.14 [0.64-2.03] | 2.59 [1.38-4.87] | 1.29 [0.34-4.89] | 1.01 [0.2-5.2] | 1.76 [1.02-3.03] | 1.75 [0.82-3.75] | 1.32 [0.76-2.31] | |||||||||||||
| >2 | 0.79 0.33-1.92] | 4.54 [1.41-14.66] | 0.25 [0.03-1.99] | 0.1 [0.01-1.71] | 2.27 [1.01-5.1] | 2.76 [0.71-10.66] | 1.17 [0.42-3.24] | |||||||||||||
| QUINTILE EDI | ||||||||||||||||||||
| 1 | 1 (reference) | 0.628 | 1 (reference) | 0.611 | 1 (reference) | 0.103 | 1 (reference) | 0.081 | 1 (reference) | 0.68 | 1 (reference) | 0.314 | 1 (reference) | 0.994 | 1 (reference) | 0.982 | 1 (reference) | 0.755 | 1 (reference) | 0.886 |
| 2 | 0.83 [0.61-1.14] | 0.85 [0.62-1.16] | 1.13 [0.67-1.92] | 1.42 [0.8-2.51] | 1.04 [0.26-4.24] | 0.92 [0.12-7.28] | 1.06 [0.59-1.89] | 1.03 [0.46-2.32] | 0.91 [0.47-1.77] | 0.87 [0.42-1.78] | ||||||||||
| 3 | 0.9 [0.66-1.23] | 0.97 [0.71-1.32] | 0.85 [0.47-1.54] | 1.03 [0.54-1.97] | 0.74 [0.2-2.8] | 0.85 [0.12-6.12] | 0.95 [0.52-1.75] | 0.97 [0.44-2.13] | 0.88 [0.44-1.75] | 0.9 [0.43-1.9] | ||||||||||
| 4 | 0.97 [0.72-1.31] | 1.01 [0.75-1.37] | 1.72 [0.96-3.06] | 1.91 [1.02-3.58] | 1.8 [0.41-7.78] | 3.56 [0.49-25.9] | 1.0 [0.56-1.81] | 1.2 [0.54-2.67] | 0.69 [0.34-1.38] | 0.73 [0.34-1.53] | ||||||||||
| 5 | 1.01 [0.77-1.34] | 1.05 [0.79-1.4] | 1.29 [0.74-2.25] | 1.79 [0.93-3.43] | 0.85 [0.23-3.11] | 1.11 [0.14-8.8] | 0.95 [0.55-1.65] | 1.13 [0.53-2.38] | 0.98 [0.53-1.81] | 0.97 [0.5-1.9] | ||||||||||
| T staging | ||||||||||||||||||||
| 1 | 1 (reference) | <0.001 | 1 (reference) | <0.001 | 1 (reference) | 0.153 | 1 (reference) | 0.034 | 1 (reference) | 0.174 | 1 (reference) | 0.171 | 1 (reference) | 0.145 | 1 (reference) | 0.222 | ||||
| 2 | 0.8 [0.66-0.98] | 0.79 [0.64-0.97] | 1.51 [1.05-2.17] | 1.61 [1.07-2.45] | NA | 1.7 [0.92-3.14] | 1.7 [0.86-3.38] | 0.38 [0.09-1.54] | ||||||||||||
| 3 | 0.53 [0.33-0.83] | 0.52 [0.33-0.81] | 1.29 [0.83-2.01] | 1.42 [0.86-2.34] | NA | 1.26 [0.67-2.4] | 1.24 [0.61-2.53] | 0.32 [0.1-1.05] | ||||||||||||
| 4 | 0.39 [0.23-0.64] | 0.36 [0.21-0.61] | 2.37 [0.32-17.37] | 2.2 [0.3-16.69] | NA | 0.96 [0.49-1.91] | 0.83 [0.39-1.76] | 0.25 [0.08-0.85] | ||||||||||||
| N staging | 0.021 | |||||||||||||||||||
| 0 | 1 (reference) | 1 (reference) | 0.038 | 1 (reference) | 0.414 | 1 (reference) | 0.707 | 1 (reference) | 0.141 | 1 (reference) | 0.189 | |||||||||
| 1 | 0.87 [0.71-1.06] | 2.54 [1.16-5.55] | 0.91 [0.16-5.1] | 1.16 [0.57-2.35] | 0.66 [0.42-1.06] | 0.67 [0.42-1.09] | ||||||||||||||
| 2 | 0.8 [0.56-1.16] | NA | 7.31 [0.44-121] | 1.37 [0.78-2.41] | 0.97 [0.55-1.73] | 0.95 [0.52-1.76] | ||||||||||||||
| 3 | 0.43 [0.22-0.84] | NA | NA | 1.31 [0.67-2.57] | NA | NA | ||||||||||||||
| M status | 0.031 | <0.001 | ||||||||||||||||||
| 0 | 1 (reference) | 1 (reference) | 1 (reference) | 0.125 | 1 (reference) | 0.002 | 1 (reference) | 0.62 | 1 (reference) | 0.828 | ||||||||||
| 1 | 0.62 [0.39-0.99] | 3.29 [1.89-5.72] | 0.6 [0.29-1.23] | 0.21 [0.07-0.62] | 0.92 [0.65-1.29] | 1.04 [0.71-1.52] | ||||||||||||||