Table 1.
Partial list of commercially available extracellular matrix (ECM)-based products of human origin fortissue reinforcement or replacement.a
| Product | Company | ECM source | Application focus | Product form (brief description) |
|---|---|---|---|---|
| AlloDerm® | LifeCell Corp. | Skin | Soft-tissue augmentation, reinforcement or replacement (e.g., abdominal wall, breast) | Dry sheet (an intact acellular matrix of natural biological components) |
| GraftJacket® | Wright Medical Technology Inc. | Skin | Soft-tissue augmentation, chronic wound treatment | Dry sheet (a thin fenestrated acellular matrix) |
| Axis™ dermis | Mentor Worldwide LLC | Dermis | Pelvic floor repair, horizontal and vertical soft-tissue augmentation in thickness and length | Dry sheet (allograft dermis consisting of solvent-dehydrated, gamma-irradiated, preserved human collagen) |
| NeoForm™ | Mentor Worldwide LLC | Dermis | Breast augmentation | Dry sheet (acellular human dermal collagen retaining its constituent elastin fibers) |
| DermaMatrix™ | Synthes Inc. | Dermis | Replacement, repair, or reinforcement of soft tissue ingrafting procedures such as root coverage and soft-tissue ridge augmentation | Dry sheet (an allograft derived from donated human skin) |
| Suspend™ | Mentor Worldwide LLC | Fascia lata | Pelvic floor reconstruction | Dry sheet (a dense matrix of collagen bundles and transverse fasciculi) |
| AlloPatch® | Musculoskeletal Transplant Foundation | Fascia lata | Rotator cuff augmentation | Dry sheet (human fascia lata from iliotibial band) |
| AlloPatch HD™ | Musculoskeletal Transplant Foundation | Dermis | Tendon reconstruction | Dry sheet (an intact or fenestrated dermal graft that preserves and maintains the natural biomechanical and biochemical matrix properties) |
| FlexHD® | Musculoskeletal Transplant Foundation | Dermis | Breast augmentation, hernia repair | Fully hydrated matrix (a strong, versatile, ready-to-use acellular dermal matrix) |
| IOPatch™ | IOP Inc. | Pericardium | Ophthalmologic repair | Dry sheet (an acellular pericardial matrix) |
| Puros® DBM | Zimmer | Bone | Bone repair (e.g., reconstruction of cavitary bone deficiency) | Allograft demineralized bone matrix (DBM) putty (a natural polymer product produced by a mineralized bone allograft following the removal of its inorganic elements using a demineralizing agent; 100% derived from allograft tissue) |
| AlloMatrix® | Wright Medical Technology Inc. | Bone | Bone repair (e.g., reconstruction of cavitary bone deficiency, augmentation in situations of segmental bone loss and interbody spinal fusion) | Injectable or formable putty (DBM combined with surgical-grade calcium sulfate that can be formed into an onlay or injected directly into a defect site) |
| AlloFuse® | AlloSource | Bone | Bone repair (e.g., reconstruction of cavitary bone deficiency) | Injectable gel or putty (DBM combined with heat-sensitive copolymer) |
| InterGro® | Biomet Osteobiologics | Bone | Bone repair (e.g., reconstruction of cavitary bone deficiency and segmental bone loss) | Paste, putty or mix containing hydroxyapatite/calcium carbonate composite granules (DBM in a lecithin carrier) |
| Grafton® | Osteotech Inc. | Bone | Bone repair (e.g., reconstruction of cavitary bone deficiency) | Gel (DBM combined with glycerol) |
| Osteofil®/Regenafil® | Regeneration Technologies | Bone | Bone repair (e.g., reconstruction of cavitary bone deficiency, augmentation in situations of segmental bone loss and interbody spinal fusion) | Injectable paste or putty, strips and blocks with cortical cancellous chips (CCC) (DBM combined with a non-toxic natural gelatin carrier) |
| Optefil® | Exactech Inc. | Bone | Bone repair (e.g., reconstruction of cavitary bone deficiency and segmental bone loss) | Injectable bone paste/dry powder ready to be hydrated (DBM suspended in a gelatin carrier) |
| Opteform® | Exactech Inc. | Bone | Bone repair (e.g., reconstruction of cavitary bone deficiency and segmental bone loss) | Formable putty or dry powder ready to be hydrated (DBM and CCC suspended in a gelatin carrier) |
| Optecure® | Exactech Inc. | Bone | Bone repair (e.g., reconstruction and augmentation of deficient maxillary and mandibular alveolar ridges and dental intraosseous defects) | Dry mix delivered with buffer solution (an optimal concentration of DBM suspended in a resorbable hydrogel carrier) |
| Optecure® +CCC | Exactech Inc. | Bone | Bone repair (e.g., reconstruction of the spine, pelvis and extremities) | 3D matrix delivered with buffer solution (DBM and CCC suspended in a hydrogel carrier) |
a
The product list does not represent any particular preference by the authors.