Table 2.

Overview of the investigated sampling schedules

Case	Measurement	Number of omitted time points	Number of combinationsa	Total no. of measurementsb	Ratio of no. of measurements to fit parameters
					Standard approach	Iterative approach
Reference	Organ + serum	0	1	33	2.5	4.1
I	Organ + serum	1	5	27	2.1	3.4
II	Organ + serum	2	10	21	1.6	2.6
III	Organ +serum	3	10	15	1.2	1.9
IV	Organ + serum	4	5	9	0.7	1.1
V	Organ	8 (serum)	1	25	1.9	3.1

^aThe number of different sampling schedules when omitting each measurement point once

^bFive organ data per time point and 8 for serum measurements